News: Biomolecular Engineering

A research team led by Stanislav Shvartsman using zebrafish and fruit flies as model organisms, has developed both a way to rank the severity of different mutations involved in RASopathies, and to show that some RASopathies result from insufficient signaling along the pathway, rather than excessive signaling as generally believed.
In a series of recent studies, scientists have unlocked the importance of the nucleolus, a tiny structure scattered throughout the nucleus, in cellular development. Now, researchers have found that the size of the nucleolus varies with the size of an organism, and within a given species, the nucleolus correlates with the size of an organism.
In a paper recently published in the highly-regarded research journal Cell, a Princeton team, led by Clifford Brangwynne and including Jared Toettcher, demonstrated the use of a new method, termed “OptoDroplet”, to induce both reversible and irreversible protein phase transitions within cells.