News: Cellular and Tissue Engineering

Slimy, hard-to-clean bacterial mats called biofilms cause problems ranging from medical infections to clogged drains and fouled industrial equipment. Now, researchers at Princeton have found a way to cleanly and completely peel off these notorious sludges.
Creating new tools that harness light to probe the mysteries of cellular behavior, Princeton researchers have made discoveries about the formation of cellular components called membraneless organelles and the key role these organelles play in cells.
For centuries, scientists have puzzled over configurations of objects that fit a given space. These packing problems not only have fascinated mathematicians, they also hold critical implications for disciplines from chemistry to shipping.
For bacteria facing a dose of antibiotics, timing might be the key to evading destruction. In a series of experiments, Princeton researchers found that cells that repaired DNA damaged by antibiotics before resuming growth had a much better chance of surviving treatment.
Most people can name at least a few bones of the human body, but not many know about the cytoskeleton within our cells, let alone the “microtubules” that give it its shape. Now, a group of Princeton researchers has resolved a long-standing controversy by identifying exactly how the body creates these micron-sized filaments.

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